High Blood Pressure or Hypertension Info

Info High Blood Pressure or Hypertension



To know what we're talking about high blood pressure or hypertension we need to understand the numbers for a blood pressure check.

For instance a quite normal blood pressure result is 120/80 millimeters of mercury (mm Hg) . The first (top) number "120" is called systolic blood pressure, which means the maximum pressure in your arm artery at the time when your heart contracts. One can also say: the pressure against the artery walls when the heart beats. The second (lower) number "80" is called diastolic pressure, meaning the resting blood pressure at the time when your heart fills up again and relaxes between beats.

mm Hg stands for millimeters of mercury, where Hg is the chemical symbol of mercury, being a unit of pressure equal to 0.001316 atmosphere. The Hg number reflects the pressure needed to raise a column of mercury for a number of millimeters within a cylinder-shaped vial. In this electronic era most of the traditional blood pressure machines have been replaced by uptodate electronic devices.

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One speaks of high blood pressure if the reading is 140/90 mm Hg or higher.
Now there's hope for those suffering from persistently raised blood pressure, also indicated as Hypertension.

Here's what we learn from the American Heart Association with regard to new treatment for high blood pressure or radio frequency treatment for bp.
A non-drug treatment that silences nerves near the kidneys safely and significantly reduced blood pressure in patients unable to control their hypertension despite taking an average of five medications, according to late breaking clinical trial research presented at the American Heart Association’s Scientific Sessions Nov. 2010.

This is the first human randomized controlled trial of therapeutic renal denervation (RDN), a procedure using a catheter-based probe inserted into the renal artery emitting high-frequency energy to deactivate nerves near both kidneys that are linked to high blood pressure. This approach is considered minimally invasive since the kidney nerves are nearby and the energy can be delivered via this catheter-based approach.

The trial, Symplicity HTN-2: International, Multicenter, Prospective, Randomized, Controlled Trial of Endovascular Selective Renal Sympathetic Denervation for the Treatment of Hypertension, compared 52 participants who were randomly assigned to catheter treatment plus medication to 54 controls who received medication alone.

“The procedure safely and successfully silences the nerves for six months, and perhaps permanently,” said Murray Esler, M.D., principal investigator of the trial and associate director of the Baker IDI Heart and Diabetes Institute in Melbourne, Australia.

“This procedure provides a revolutionary, non-drug method for controlling high blood pressure in patients who are unresponsive to multiple antihypertensive drugs,” he said. “Resistant hypertension is common, occurring in perhaps 15 percent to 20 percent of patients. This procedure is likely to have very wide application.”

At the start of the study, the two groups had nearly identical average blood pressures: 178/98 millimeters of mercury (mm Hg) for the treatment group versus 178/97 mm Hg for controls. Participants were average age 58, 35 percent were female and 97 percent were Caucasian.

Data at six months showed the treatment group’s systolic pressure (the top number in a blood pressure measurement) fell an average 33.4 mm Hg while diastolic pressure (the lower number) dropped an average 12.5 mmHg. In contrast, controls’ average systolic pressure rose slightly (0.9 mmHg) and their average diastolic pressure fell slightly (0.3 mm Hg).

“In a small minority of patients in the study, some high blood pressure medication could be stopped or reduced,” Esler said.

In addition, of the 48 RDN patients for whom the researchers had complete data when the news release was written, 93.8 percent had at least a 5 mm Hg reduction in systolic blood pressure and 87.5 percent had at least a 10 mm Hg drop in systolic blood pressure, Esler said.

Systolic pressure represents the pressure against the artery walls when the heart beats. Diastolic pressure reflects the pressure between beats.

In approximately 39 percent of those who received RDN, compared to six percent of the control group, blood pressure was reduced to less than 140/90 mm Hg. Pressure below 140/90 mm Hg is considered controlled to target despite being higher than the120/80 mmHg considered ideal for adults.

“Target blood pressure is usually unattainable with drug therapy in patients with severely resistant hypertension,” Esler said.

The study found no serious device or procedure-related events, no cardiovascular complications and no kidney-related complications.

Esler said the results are significant from a public health standpoint because of high blood pressure’s well-documented link to the development of heart attack and stroke, and because hyperactivity of the renal nerves is seen in chronic kidney disease, heart failure and high blood pressure. Future studies will evaluate the effects of the new high blood presure treatment on those conditions.

While the study population was not ethnically diverse, Esler said he expected the findings to extend across all groups.

Co-authors include members of the Symplicity HTN-2 study group. Author disclosures are on the abstract.
Ardian Inc., funded the study (maker of the Symplicity® Catheter System™).

Source: American Heart Association and search there: RDN. Another source is Erasmus Medical Center or http://www.erasmusmc.nl/perskamer/archief/2010/2866444/?lang=en

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